H-9 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

H-9 Dihydrochloride 是一种 PKA (蛋白激酶)抑制剂。H-9 Dihydrochloride (10 μM) 显著降低 5-HT 的兴奋性反应。H-9 Dihydrochloride 对咽部活动也有直接影响。H-9 Dihydrochloride 抑制 EGF (表皮生长因子)依赖的上皮细胞系的信号转导和细胞生长。

H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines.

H-9 Dihydrochloride significantly inhibits A431 cells.H-9 Dihydrochloride inhibits more effectively cyclic nucleotide-dependent protein kinases than other kinases.

H-9 Dihydrochloride microperfusion (100 μM) prevents picrotoxin seizures in 50% of the animals and significantly reduced the mean number of seizures and mean seizure duration.

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Apoptosis

PKA

PKA | EGFR | 5-HT Receptor

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116700-36-8

324.23

C11H15Cl2N3O2S

>98% (HPLC)

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O=S(NCCN)(C1=CC=CC2=C1C=CN=C2)=O.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years